Applied Therapeutics is committed to developing transformative treatments for high unmet medical need indications - fatal or debilitating diseases with no drugs approved.

COVID-19 Statement

Our clinical trials are designed to incorporate home visits to limit travel and risk of exposure to COVID-19.

Scientist putting liquid from dropper in test tube

Interested in participating in one of our clinical trials?

Galactosemia Trials:

Contact us at Galactosemia@appliedtherapeutics.com or call 212-220-9226

Diabetic Cardiomyopathy Trial:

Contact us at info@appliedtherapeutics.com or call 212-220-9226

ACTION-Galactosemia

Applied Therapeutics has completed a Phase 1/2 study of AT-007 in adults (age 18 and older) with Galactosemia. ACTION-Galactosemia evaluated the safety and pharmacokinetics (PK) of AT-007, a central nervous system (CNS) penetrant Aldose Reductase Inhibitor, in healthy volunteers, and explored safety, PK and biomarker effects in adult subjects with Galactosemia. Applied Therapeutics is now conducting a long-term extension with adult study participants.

ACTION-Galactosemia Kids

Applied Therapeutics is currently conducting a pediatric study of AT-007 in children (age 2-17) with Galactosemia. Similar to the ACTION-Galactosemia trial in adults, the pediatric study will evaluate safety, pharmacokinetics, and reduction in the toxic biomarker, galactitol as well as long-term clinical outcomes, such as speech, memory, cognition, behavior, growth and development, and motor skills.

ARISE-HF

Applied Therapeutics is currently enrolling a Phase 3 clinical trial of AT-001 in adults with Type 2 Diabetes for Diabetic Cardiomyopathy (DbCM). ARISE-HF is evaluating whether AT-001 can improve or prevent the decline of functional capacity in patients with DbCM.